Christina Applegate has reportedly been hospitalized amid her ongoing battle with Multiple Sclerosis (MS), a disease wherein the immune system attacks the protective layer around the nerves, leading to incredibly painful symptoms.
The 54-year-old, who announced her diagnosis to the world in 2021, was reportedly admitted to hospital in late March, according to TMZ. Christina's representative shared a statement in the wake of the news, which read: "I have no comment on whether she is in the hospital or what her medical treatments are."
"She's had a long history of complicated medical conditions that she has been refreshingly open about, as evidenced in her memoir and on her podcast," they concluded. It is unclear if Christina was hospitalized for reasons relating to her MS.
© Getty ImagesHer MeSsy podcast co-host, Jamie-Lynn Sigler, shared on March 31 that their podcast would be going on a brief hiatus as they were "both busy with our books coming out". Christina released her memoir, You With the Sad Eyes, on March 3.
The mother of one has been honest about the pain and trauma that comes with living with MS, and shared on her MeSsy podcast that she had been hospitalized dozens of times since receiving her diagnosis.
"For three years, since I was diagnosed, I've been in the hospital upwards of 30 times from throwing up and diarrhea and pain that is unimaginable," she explained. "They've done every test known to man on me, put so much radiation into my body from CT scans to everything else."
© Variety via Getty ImagesShe was also hospitalized in 2025 due to a kidney infection that left her "screaming" in pain. "I'm staying here because I want answers. I want every test that you can possibly think of or ones that you haven't even thought of, and I want them done," she said on the podcast.
Learn more about Christina's health battle below...
Christina has made it her mission to help others living with MS, and recently launched an online platform to allow patients to share their experiences with the community. The platform, named Next in MS, will encourage people to discuss "the good, the bad, the ugly, the in-betweens, the diapers, the things, whatever it is," as Christina shared in a press release.
"Together, hopefully we can reach more members of the MS community, cut through the noise and talk openly about the truths of living with MS – the challenging ones and the hopeful ones too."
© InstagramChristina revealed her MS diagnosis for the first time in 2021 in an emotional social media statement. "Hi friends. A few months ago, I was diagnosed with MS. It's been a strange journey. But I have been so supported by people that I know who also have this condition," she wrote.
© Getty Images"It's been a tough road. But as we all know, the road keeps going. Unless some [expletive] blocks it. As one of my friends that has MS said, 'We wake up and take the indicated action.' And that's what I do. So now I ask for privacy. As I go through this thing. Thank you xo."
The Dead to Me actress shares her only daughter, 15-year-old Sadie, with her husband, Martyn LeNoble. Sadie supported her mom during her appearance at the 2024 Emmy Awards, where Christina received a standing ovation as she came out to present an award.
